Lab trip to the Sweet Havana Restaurant
Cedar point trip
Lab trip to the Sweet Havana Restaurant Read More »
Publication – Microwave-Assisted Neutral Glycosylation Reactions in the Absence of Reagent Activators
Abstract Use of a microwave-labile leaving group, 2,4-dinitrophenyl (2,4-DNP), leads to O-glycosylation in 70–80% yields with high α-selectivity. The 2,4-DNP glycosyl donors, protected with electron-donating benzyl ethers, gave the best results under controlled microwave conditions, which were all conducted in polar aprotic solvents, such as DMF, and were all conducted in the absence of any reagent-activating
Publication – Synthesis and inhibition studies of substrate analogues for MshC (cysteine ligase) enzyme in Mycobacterium tuberculosis
Abstract Mycothiol cysteine ligase (MshC) from Mycobacterium tuberculosis (TB) plays a vital role in the biosynthesis of mycothiol (MSH) and can serve as a potential target for designing novel anti-mycobacterial compounds. Herein we report the synthesis of MshC substrate GlcN-Ins and substrate-based analogues as potential inhibitors for MshC. We obtained IC50 values in the micromolar range for our
Graduation of Géraud Valentin
Graduation of Dr. Géraud Valentin
Graduation of Géraud Valentin Read More »
Publication – The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses
Abstract The MHCII-dependent, CD4+ T-cell zwitterionic polysaccharide PS A1 has been investigated as a promising carrier for vaccine development because it can induce an MHCII-dependent CD4+ response towards a variety of tumor-associated carbohydrate antigens (TACAs). However, PS A1 cannot elicit cytotoxic T lymphocytes through MHCI, which may or may not hamper its potential clinical use
Publication – The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses Read More »
Graduation of Matthew Lohman
Graduation of Dr. Matthew Lohman
Graduation of Matthew Lohman Read More »
