Publications
Publication List
65. Rosenglick, N.; Valentin, G.; Marineni, K.; Neto, E.P.; Andreana, P.R. Conjugate Vaccines Targeting Tumor-Associated Carbohydrate Antigens. Vaccines 2026, 14(4), 287. DOI : 10.3390/vaccines14040287
64. Valentin, G.; Satriani, A.; Eradi, P.; Lohman, M.; Andreana, P.R. “Click” chemistry for the assembly of entirely carbohydrate-based vaccines. Organic & Biomolecular Chemistry 2026, 24(27), 5655-5660. DOI : 10.1039/D6OB00208K
63. Gamage, S.M.P.; Valentin, G.; Ghosh, S.; Eradi, P.; Bagul, R.S.; Crich, D.; Andreana, P.R. Microwave-Assisted Neutral Glycosylation Reactions in the Absence of Reagent Activators. Molecules 2025, 30(18), 3693. DOI : 10.3390/molecules30183693
62. Liyanarachchi, A. J.; Valentin, G.; Andreana P. R. Synthesis and inhibition studies of substrate analogues for MshC (cysteine ligase) enzyme in Mycobacterium tuberculosis. Carbohydrate Research 2025, 558, 109652. DOI : 10.1016/j.carres.2025.109652
61. Nishat, S.; Hossain, M. K.; Valentin, G.; Hossain, F.; Gamage, S.; Wall, K. A.; Andreana P. R. The glycopeptide PV-PS A1 immunogen elicits both CD4+ and CD8+ responses. Vaccines 2024, 12(12), 1375. DOI : 10.3390/vaccines12121375
60. Xavier, N.M.; Andreana P. R. Glycomimetics and glycoconjugates in Drug Discovery. Pharmaceuticals 2024, 17(3), 323. DOI : 10.3390/ph17030323
59. Hossain, F.; Nishat, S.; Andreana P. R. Synthesis of malformin-A1, C, a glycan, and an aglycon analog: Potential scaffolds for targeted cancer therapy. Peptide Science 2022, 114(4), e24260. DOI : 10.1002/pep2.24260
58. Andreana, P. R.; Crich D. Guidelines for O-Glycoside Formations from First Principles. ACS Central Science 2021, 7(9), 1454-1462. DOI : 10.1021/acscentsci.1c00594
57. Ghosh, S.; Trabbic, K. R.; Shi, M.; Nishat, S.; Eradi, P.; Kleski, K. A.; Andreana, P. R. Chemical Synthesis and Immunological Evaluation of Entirely Carbohydrate Conjugate Globo H-PS A1. Chemical Science 2020, 11(48), 13052-13059. DOI: 10.1039/D0SC04595K
56. Kleski, K. A.; Shi, M.; Lohman, M.; Hymel, G.; Gattoji, V.; Andreana, P. R. Synthesis of an Aminooxy Derivative of the GM3 Antigen and its Application in Oxime Ligation. The Journal of Organic Chemistry 2020, 85(24),16207-16217. DOI: 10.1021/acs.joc.0c00320
55. Trabbic, K. R.; Bourgault, J.-P.; Shi, M.; Kleski, K. A.; Andreana, P. R. Enhanced Immune Response Against the Thomsen-Friedenreich Tumor Antigen Using a Bivalent Entirely Carbohydrate Conjugate. Molecules 2020, 25(6), 1319. DOI: 10.3390/molecules25061319
54. Hossain, F.; Nishat, S.; Ghosh, S.; Boga, S.; Hymel, G. T.; Andreana, P. R. Synthesis of Glycoimmunogen Tn-Thr-PS A1 via Hydrazone Bond and Stability Optimization of PS A1 Monosaccharide Mimics Under Vaccine Development Conditions. Journal of Carbohydrate Chemistry 2020, 39(2-3), 107-129. DOI: 10.1080/07328303.2019.1709975
53. Kleski, K. A.; Andreana, P. R. Developments in CRM197 Glycoconjugates for Anticancer Vaccines. American Journal of Biomedical Science & Research 2019, 6(3), 212-215. DOI: 10.34297/AJBSR.2019.06.001031
52. Hossain, F.; Andreana, P. R. Developments in Carbohydrate-Based Cancer Therapeutics. Pharmaceuticals 2019, 12(2), 84. DOI: 10.3390/ph12020084
51. Hohol, R. E.; Arcure, H.; Witczak, Z.; Bielski, R.; Kirschbaum, K.; Andreana, P.; Mencer, D. E. One-Pot Synthesis of Carbohydrate exo-Cyclic Enones and Hemiketals with 6,8-Dioxabicyclo-[3.2.1]Octane Moieties. Serendipitous Formation of a Spironolactone when 2-Pyridinecarboxaldehyde is used as the Reactant. Part II. Tetrahedron 2018, 74(51), 7303-7309. DOI: 10.1016/j.tet.2018.10.049
50. Eradi, P.; Ghosh, S.; Andreana, P. R. Total Synthesis of Zwitterionic Tetrasaccharide Repeating Unit from Bacteroides fragilis ATCC 25285/NCTC 9343 Capsular Polysaccharide PS A1 with Alternating Charges on Adjacent Monosaccharides. Organic Letters 2018, 20(15), 4526-4530. DOI: 10.1021/acs.orglett.8b01829
49. Trabbic, K. R.; Kleski, K. A.; Shi, M.; Bourgault, J.-P.; Prendergast, J. M.; Dransfield, D. T.; Andreana, P. R. Production of a Mouse Monoclonal IgM Antibody that Targets the Carbohydrate Thomsen-nouveau Cancer Antigen Resulting in in vivo and in vitro Tumor Killing. Cancer Immunology and Immunotherapy 2018, 67, 1437-1447. DOI: 10.1007/s00262-018-2206-0
48. Esmati, N.; Maddirala, A. R.; Hussein, N.; Amawi, H.; Tiwari, A. K.; Andreana, P. R. Efficient Syntheses and Anti-Cancer Activity of Xenortides A-D Including ent/epi-Stereoisomers. Organic & Biomolecular Chemistry 2018, 16(29), 5332-5342. DOI: 10.1039/C8OB00452H
47. Maddirala, A. R.; Andreana, P. R. Methyl Isocyanide as a Convertible Functional Group for the Synthesis of Spirocyclic Oxindole γ–Lactams via Post Ugi-4CR/Transamidation/Cyclization in a One-Pot Three Step Sequence. Beilstein Journal of Organic Chemistry 2018, 14, 875-883. DOI: 10.3762/bjoc.14.74
46. Patel, K.; Song, F.; Andreana, P. R. Synthesis of Substrate Analogues as Potential Inhibitors for Mycobacterium tuberculosis enzyme MshC. Carbohydrate Research 2017, 453-454, 10-18. DOI: 10.1016/j.carres.2017.10.014
45. Jeelani, R.; Jahanbakhsh, S.; Kohan-Ghadr, H.-R.; Thakur, M.; Khan, S.; Aldhaheri, S. R.; Yang, Z.; Andreana, P. R.; Morris, R.; Abu-Souda, H. M. Mesna (2-Mercaptoethane Sodium Sulfonate) Functions as a Regulator of Myeloperoxidase. Free Radical Biology and Medicine 2017, 110, 54-62. DOI: 10.1016/j.freeradbiomed.2017.05.019
44. Shi, M.; Kleski, K. A.; Trabbic, K. R.; Bourgault, J.-P.; Andreana, P. R. STn-PS A1 as an Entirely Carbohydrate Immunogen: Synthesis and Immunological Evaluation. Journal of the American Chemical Society 2016, 20(15), 4526-4530. DOI: 10.1021/jacs.6b05675
43. Nishat, S.; Andreana, P. R. Entirely Carbohydrate-based Vaccines: An Emerging Field for Specific and Selective Immune Responses. Vaccines 2016, 4(2), 19. DOI: 10.3390/vaccines4020019
42. Ghosh, S.; Nishat, S.; Andreana, P. R. Synthesis of an Aminooxy Derivative of the Tetrasaccharide Repeating Unit of Streptococcus dysgalactiae 2023 Polysaccharide and a PS A1 Conjugate Vaccine. Journal of Organic Chemistry 2016, 81(11), 4475-4484. DOI: 10.1021/acs.joc.6b00195
41. Trabbic, K. R.; Bourgault, J.-P.; Shi, M.; Clark, M.; Andreana, P. R. Immunological Evaluation of the Entirely Carbohydrate-based Thomsen-Friedenreich – PS B Conjugate. Organic and Biomolecular Chemistry 2016, 14(13), 3350-3355. DOI: 10.1039/C6OB00176A
40. Maddirala, A. R.; Andreana, P. R. Synthesis of 3-Substituted-2-Indolinones via a Multicomponent Coupling Isocyanide Dependent Microwave-Assisted Intramolecular Transamidation Process. European Journal of Organic Chemistry 2016, 2016(1), 196-209. DOI: 10.1002/ejoc.201501273
39. Ghosh, S.; Andreana, P. R. Di-t-butylsilyl Bis(trifluoromethanesulfonate). e-EROS (Encyclopedia of Reagents for Organic Synthesis) 2015 DOI: 10.1002/047084289X.rd069.pub2
38. Shaik, A. A.; Nishat, S.; Andreana, P. R. Stereoselective Synthesis of Natural and Non-natural Thomsen-nouveau Antigens and Hydrazide Derivatives. Organic Letters 2015, 17(11), 2582-2585. DOI: 10.1021/acs.orglett.5b00512
37. Andreana, P.R. Click Chemistry in Glycoscience: New Developments and Strategies. Journal of Carbohydrate Chemistry 2014, 33(9), 506-508. DOI: 10.1080/07328303.2014.957386
36. Bourgault, J. P.; Maddirala, A.; Andreana, P. R. A One-Pot Multicomponent Coupling/Cyclization for Natural Product Herbicide (±)-Thaxtomin A. Organic and Biomeolecular Chenistry 2014, 12(41), 8125-8127. DOI : 10.1039/C4OB01148A
Jean-Paul Bourgault completes the total synthesis of naturally occurring herbicide Thaxtomin A in a single synthetic transformation using a facile, streamlined and efficient multicomponent one-pot process. For his efforts, Mr. Bourgault was granted the inside cover of OBC as illustrated here. Although Thaxtomin A had been synthesized previously, this short route hopes to provide a library of Thaxtomin A derivatives that will be used to probe the compound’s mechanism of action as it is currently still unknown. One of the keys to Jean-Paul’s strategy is that the by-product of this reaction is water which bodes well with Thaxtomin A’s story of being Bio-Friendly.
In addition a modified version of this article was published on the Royal Society of Chemistry learn chemistry web site under the annotated article section. This resource is aimed at teaching undergraduate students how to understand and interpret key aspects of journal articles through clearly defined outlines which are rewritten by the authors specifically for the students. Please click here for more information !
35. Ghosh, S.; Andreana, P. R. Synthesis of an Aminooxy Derivative of the Trisaccharide Globotriose Gb3. Journal of Carbohydrate Chemistry 2014, 33(7-8), 381-394. DOI: 10.1080/07328303.2014.925913
34. Trabbic, K. R.; De Silva, R. A; Andreana, P. R. Elucidating Structural Features of an Entirely Carbohydrate Cancer Vaccine Construct Employing Circular Dichroism and Fluorescent Labeling. Medicinal Chemistry Communications 2014, 5(8), 1143-1149. DOI: 10.1039/C4MD00038B
33. Bourgault, J. P.; Trabbic, K. R.; Shi, M.; Andreana, P. R. Synthesis of the Tumor Associative α-Aminooxy Disaccharide of the TF Antigen and its Conjugation to a Polysaccharide Immune Stimulant. Organic and Biomolecular Chemistry 2014, 12(11), 1699-1702. DOI: 10.1039/C4OB00128A
32. Abu-Soud, H. M.; Maitra, D.; Shaeib, F.; Byun, J.; Abdulhamid, I.; Saed, G. M.; Diamond, M. P.; Andreana, P. R.; Pennathur, S. Disruption of Heme-Peptide Covalent Cross-Linking in Mammalian Peroxidases by Hypochlorous Acid. Journal of Inorganic Biochemistry 2014, 140, 245-254. DOI: 10.1016/j.jinorgbio.2014.06.018
31. De Silva, R. A.; Appulage, D. K.; Pietraszkiewicz, H.; Bobbitt, K. R.; Media, J.; Shaw, J.; Valeriote, F. A.; Andreana, P. R. The Entirely Carbohydrate Immunogen Tn-PS A1 Induces a Cancer Cell Selective Immune Response and Cytokine IL-17. Cancer Immunology, Immunotherapy 2012, 61, 581-585. DOI: 10.1007/s00262-012-1205-9
30. Shaw, J.; Chen, B.; Bourgault, J. P.; Jiang, H.; Kumar, N.; Mishra, J.; Valeriote, F. A.; Media, J.; Bobbitt, K.; Pietraszkiewicz, H.; Edelstein, M.; Andreana, P. R. Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer. American Journal of Biomedical Sciences 2012, 4(1), 14-25. DOI: 10.5099/aj120100014
29. Abu-Soud, H. M.; Maitra, D.; Byun, J.; Souza, C. E. A.; Banerjee, J.; Andreana, P. R.; Pennathur, S. The Reaction of HOCl and Cyanocobalamin: Corrin Destruction and the Liberation of Cyanogen Chloride. Free Radical Biology and Medicine 2012, 52(3), 616-625. DOI: 10.1016/j.freeradbiomed.2011.10.496
28. Santra, S.; Andreana, P.R. A Bioinspired Ugi/Michael/aza-Michael Cascade reaction in Aqueous Media: Natural-Product-like Molecular Diversity. Angewandte Chemie International 2011, 50(40), 9418-9422. DOI: 10.1002/anie.201103567
27. Maitra, D.; Byun, J.; Andreana, P. R.; Abdulhamid, I.; Diamond, M. P.; Saed, G. M.; Pennathur, S.; Abu-Soud, S. M. Reaction of Hemoglobin with HOCl: Mechanism of Heme Destruction and Free Iron Release. Free Radical Biology and Medicine 2011, 51(2), 374-386. DOI: 10.1016/j.freeradbiomed.2011.04.011
26. Maitra, D.; Byun, J.; Andreana, P. R.; Abdulhamid, I.; Saed, G. M.; Diamond, M. P.; Pennathur, S.; Abu-Soud, S. M. Mechanism of Hypochlorous Acid-Mediated Heme Destruction and Free Iron Release. Free Radical Biology and Medicine 2011, 51(2), 364-373. DOI: 10.1016/j.freeradbiomed.2011.03.040
25. Santra, S.; Jonas, E.; Bourgault J.-P.; El-Baba, T.; Andreana, P. R. Kinetic Products Under Thermal Conditions: Rapid Entry into Anomeric Substituted a/b-D-Galactofuranosides Using Microwave Irradiation and Selective Lewis Acids. Journal of Carbohydrate Chemistry 2011, 30(1), 27-40. DOI: 10.1080/07328303.2011.585259
24. Santra, S.; Andreana, P. R. A Rapid, One-Pot, Microwave-Influenced Synthesis of Spiro-2,5-Dikopiperazines via a Cascade Ugi/6-exo-trig aza-Michael Reaction. Journal of Organic Chemistry 2011, 76(7), 2261-2264. DOI: 10.1021/jo102305q
23. De Silva, R. A.; Wang, Q.; Chidley, T.; Appulage, D. K.; Andreana, P. R. Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn-PS A1 Conjugates. Journal of the American Chemical Society 2009, 131 (28), 9622-9623. DOI: 10.1021/ja902607a
22. Yatawara, A. K.; Tiruchinapally, G.; Bordenyuk, A. N.; Andreana, P. R.; Benderskii, A. V. Carbohydrate Surface Attachment Characterized by Sum Frequency Generation Spectroscopy. Langmuir 2009, 25 (4), 1901-1904. DOI: 10.1021/la803113h
21. De Silva, R. A.; Santra, S.; Andreana, P. R. A Tandem One-Pot, Microwave-Assisted Synthesis of Regiochemically Differentiated 1,2,4,5-Tetrahydro-1,4-benzodiazepin-3-ones. Organic Letters 2008, 10(20), 4541-4544. DOI: 10.1021/ol801841m
Highlighted In: Organic Chemistry Portal (Org. Chem. Highlights) October 15, 2008.
20. Santra, S.; Andreana, P. R. A One-Pot, Microwave-Influenced Synthesis of Diverse Small Molecules by Multicomponent Reaction Cascades. Organic Letters 2008, 9(24), 5035-5038. DOI: 10.1021/ol702256t
Highlighted In: Organic Chemistry Portal (Org. Chem. Highlights) November 15, 2007.
19. Andreana, P. R.; Liu, C. C.; Schreiber, S. L. Stereochemical Control of the Passerini Reaction. Organic Letters 2004, 6(23), 4231-4233. DOI : 10.1021/ol0482893
18. Andreana, P. R.; Kowal, P.; Janczuk, A. J.; Wang, P. G. Alpha-Galactosyl Trisaccharide Epitope: Modification of the 6-Primary Positions and Recognition by Human Anti-alpha-Gal Antibody. Glycoconjugate Journal 2003, 20, 107-118. DOI: 10.1023/B:GLYC.0000018585.66094.ff
17. Sello, J. K.; Andreana, P. R.; Lee, D.; Schreiber, S. L. Stereochemical Control of Skeletal Diversity. Organic Letters 2003, 5(22), 4125-4127. DOI: 10.1021/ol035773h
16. Postema, M. H. D.; Piper, J. L.; Liu, L.; Shen, J.; Faust, M.; Andreana, P. Synthesis and Partial Biological Evaluation of a Small Library of Differentially-Linked -C-Disaccharides. Journal of Organic Chemistry 2003, 68(12), 4748-4754. DOI: 10.1021/jo030039x
15. Andreana, P. R.; McLellan, J. S.; Chen, Y.; Wang, P. G. Synthesis of 2,6-Dideoxysugars via Ring Closing Olefinic Metathesis. Organic Letters 2002, 4(22), 3875-3878. DOI: 10.1021/ol026710m Hot Article Oct./02. Cited in C&EN News Dec. 23/02.
14. Andreana, P. R.; Sanders, T.; Janczuk, A.; Warrick, J. I.; Wang, P. G. Chemo-Enzymatic Synthesis of Polyhydroxyazepanes. Tetrahedron Letters 2002, 43(37), 6525-6528. DOI: 10.1016/S0040-4039(02)01465-X
13. Janczuk, A. J.; Zhang, W.; Andreana, P. R.; Warrick, J.; Wang P. G. The Synthesis of Deoxy alpha-Gal Epitope Derivatives for the Evaluation of Anti-alpha-Gal Antibody Binding. Carbohydrate Research 2002, 337(14), 1247-1259. DOI: 10.1016/S0008-6215(02)00159-3
12. Andreana, P. R.; Xie, W.; Cheng, H. N.; Qiao, L.; Murphy, D. J.; Gu, Q. M.; Wang, P. G. In-Situ Preparation of beta-D-1-O-Hydroxylamino Carbohydrate Polymers Mediated by Galactose Oxidase. Organic Letters 2002, 4(11), 1863-1866. DOI: 10.1021/ol0258379
11. Zhang, J.; Kowal, P.; Fang, J.; Andreana, P.; Wang, P. G. (2002) Efficient Chemoenzymatic Synthesis of Globotriose and Its Derivatives with a Recombinant alpha-(1-4)-Galactosyltransferase. Carbohydrate Research 2002, 337(11), 969-976. DOI: 10.1016/S0008-6215(02)00106-4
10. Chen, X.; Zhang, J.; Kowal, P.; Liu, Z.; Andreana, P. R.; Lu, Y.; Wang, P. G. Transferring a Biosynthetic Cycle into a Productive Escherichia coli Strain: Large-Scale Synthesis of Galactosides. Journal of the American Chemical Society 2001, 123(36), 8866-8867. DOI: 10.1021/ja016187r
9. Chen, X.; Fang, J.; Zhang, J.; Andreana, P. R.; Shao, J.; Kowal, P.; Wang, P. G. Sugar Nucleotide Regeneration Beads (Superbeads): A Versatile Tool for Practical Synthesis of Oligosaccharides. Journal of the American Chemical Society 2001, 123(9), 2081-2082. DOI: 10.1021/ja005738v
8. Holland, H. L.; Andreana, P. R.; Salehzadeh-Asl, R.; van Vliet, A.; Ihasz, N. J.; Brown, F. M. Beauveria bassiana ATCC 7159 Contains an L-Specific alpha-Amino Acid Benzamidase. Monatshefte für Chemie 2000, 131, 6767-672. DOI: 10.1007/s007060070095
7. Hou, Y. -C.; Chen, Y. -S.; Amro, N. A.; Wadu-Mesthrige, K.; Andreana, P. R.; Wang, P. G. Nano-Molar Scale Nitric Oxide Generation From Self-Assembled Monolayer Modified Gold Electrodes. Chemical Communication 2000, 19, 1831-1832. DOI: 10.1039/B004159I Editor’s Choice in Science, Oct. 13/00.
6. Fang, J. W.; Chen, X.; Zhang, W.; Wang, J. Q.; Andreana, P. R.; Wang, P. G. A Unique Chemoenzymatic Synthesis of alpha-Galactosyl Epitope Derivatives Containing Free Amino Groups: Efficient Separation and Further Manipulation. Journal of Organic Chemistry 1999, 64(11), 4089-4094. DOI: 10.1021/jo990159y
5. Chen, X.; Andreana, P. R.; Wang, P. G. Carbohydrates in Transplantation. Current Opinion in Chemical Biology 1999, 3(6), 650-658. DOI: 10.1016/S1367-5931(99)00022-8
4. Hou, Y.-C.; Wang, J.-Q.; Andreana, P. R.; Cantauria, G.; Tarasia, S.; Sharp, L.; Braunschweiger, P. G.; Wang, P. G. Targeting Nitric Oxide to Cancer Cells: Cytotoxicity Studies of Glyco-S Nitrosothiols. Bioorganic and Medicinal Chemistry Letters 1999, 9(15), 2255-2258. DOI: 10.1016/S0960-894X(99)00363-7
3. Holland, H. L.; Turner, C. D.; Andreana, P. R.; Nguyen, D. Biotransformation of Organic Sulfides. Part 12. Conversion of Heterocyclic Sulfides to Chiral Sulfoxides by Helminthosporium sp NRRL 4671 and Mortierella isabellina ATCC 42613. Canadian Journal of Chemistry – Revue Canadienne de Chimie 1999, 77(4), 463-471. DOI: 10.1139/v99-068
2. Holland, H. L.; Andreana, P. R.; Brown, F. M. Biocatalytic and Chemical Routes to all the Stereoisomers of Methionine and Ethionine Sulfoxides. Tetrahedron: Asymmetry 1999, 10(15), 2833-2843. DOI: 10.1016/S0957-4166(99)00271-2
1. Holland, H. L.; Kohl, A.; Larsen, B. G.; Andreana, P.; Gu, J. X. Preparation of Substituted (R)-2-Alkanols by Microbial Hydroxylation. Journal of Molecular Catalysis B-Enzymatic 1997, 2(6), L253-L255. DOI: 10.1016/S1381-1177(97)00002-7
Patents
Monoclonal IgM Antibodies from Entirely Carbohydrate Constructs (US20240092932A1 – Previously PCT/US2017/052169 – WO/2018/053468).
