Abstract The immunogenicity of conjugate vaccines is affected by the type of linker used. Due to its ease of synthesis, the “click” triazole linker is now widely used, but its impact on vaccine immunogenicity remains understudied, and current findings are contradictory due to the difficulty of isolating the linker’s effect. To finally quantify the effect
Abstract The MHCII-dependent, CD4+ T-cell zwitterionic polysaccharide PS A1 has been investigated as a promising carrier for vaccine development because it can induce an MHCII-dependent CD4+ response towards a variety of tumor-associated carbohydrate antigens (TACAs). However, PS A1 cannot elicit cytotoxic T lymphocytes through MHCI, which may or may not hamper its potential clinical use
Publication – The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses Read More »
Department of Chemistry and Biochemistry and
School of Green Chemistry and Engineering
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