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Publication – Microwave-Assisted Neutral Glycosylation Reactions in the Absence of Reagent Activators

Abstract Use of a microwave-labile leaving group, 2,4-dinitrophenyl (2,4-DNP), leads to O-glycosylation in 70–80% yields with high α-selectivity. The 2,4-DNP glycosyl donors, protected with electron-donating benzyl ethers, gave the best results under controlled microwave conditions, which were all conducted in polar aprotic solvents, such as DMF, and were all conducted in the absence of any reagent-activating […]

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Publication – Synthesis and inhibition studies of substrate analogues for MshC (cysteine ligase) enzyme in Mycobacterium tuberculosis

Abstract Mycothiol cysteine ligase (MshC) from Mycobacterium tuberculosis (TB) plays a vital role in the biosynthesis of mycothiol (MSH) and can serve as a potential target for designing novel anti-mycobacterial compounds. Herein we report the synthesis of MshC substrate GlcN-Ins and substrate-based analogues as potential inhibitors for MshC. We obtained IC50 values in the micromolar range for our

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Publication – The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses

Abstract The MHCII-dependent, CD4+ T-cell zwitterionic polysaccharide PS A1 has been investigated as a promising carrier for vaccine development because it can induce an MHCII-dependent CD4+ response towards a variety of tumor-associated carbohydrate antigens (TACAs). However, PS A1 cannot elicit cytotoxic T lymphocytes through MHCI, which may or may not hamper its potential clinical use

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Publication – Glycomimetics and glycoconjugates in Drug Discovery

Abstract This Special Issue of Pharmaceuticals presents one review and six original articles that are demonstrative of the importance of glycomimetics and glycoconjugates as privileged groups of carbohydrate-based molecules in the search for and development of bioactive substances for therapeutic/pharmaceutical purposes. Carbohydrates and glycoconjugates play important roles in biological events that are relevant for life and the

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Publication Recognition – 2020 JCC Best Paper Award

Abstract Previously, our group constructed several immunogens utilizing oxime linkage to conjugate a T-cell stimulatory zwitterionic polysaccharide PS A1 and tumor associated carbohydrate antigens (TACAs) in acetate buffer. Here, a semi-synthetic immunogen was synthesized using hydrazone conjugation between PS A1 and a glycopeptide hydrazide (α-D-GalNAc-L-Thr-NH-NH2) with an excellent loading in PBS buffer. To get robust

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