Melissa Macauley

Abstract This Special Issue of Pharmaceuticals presents one review and six original articles that are demonstrative of the importance of glycomimetics and glycoconjugates as privileged groups of carbohydrate-based molecules in the search for and development of bioactive substances for therapeutic/pharmaceutical purposes. Carbohydrates and glycoconjugates play important roles in biological events that are relevant for life and the […]

Abstract Previously, our group constructed several immunogens utilizing oxime linkage to conjugate a T-cell stimulatory zwitterionic polysaccharide PS A1 and tumor associated carbohydrate antigens (TACAs) in acetate buffer. Here, a semi-synthetic immunogen was synthesized using hydrazone conjugation between PS A1 and a glycopeptide hydrazide (α-D-GalNAc-L-Thr-NH-NH2) with an excellent loading in PBS buffer. To get robust